megavideolinks
Joined: 19 Nov 2011
Posts: 273
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 Posted: Sat Nov 26, 2011 11:24 am Post subject: Statistical Method |
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Vascular responses to high and low PM1 exposure and preand postcuff ischemia were compared using two-tailed paired
t-tests. Pearson product moment correlation was used to evaluate the association between brachial artery FMD response to
forearm muscle reoxygenation slope. A criterion alpha of p ≤
.05 was used to determine statistical significance. All data are
reported as mean ± SD.
FIG. 1. Brachial artery diameter change before and after 30 min
of exercise while breathing low or high [PM1]. High [PM1]
inhalation during exercise resulted in significant vasoconstriction ( p = .0002). Pre-EX, preexposure; Post-EX, postexposure.
Values presented as mean ± SE.
RESULTS
Basal brachial artery diameter changes from pre- to post- PM1
exercise exposures are depicted in Figure 1. High-resolution ultrasound measurements of the brachial artery diameter before
and after 30 min of high [PM1] exercise showed a statistically
significant 4% vasoconstriction (4.66 ± 0.609 mm vs. 4.47 ±
0.625 mm, for pre- and postexposure exercise, respectively; p =
.0002). No vasoconstriction was evident after 30 min of exercise in low [PM1] (4.66 ± 0.626 mm vs. 4.68 ± 0.613 mm
diameter, for pre- and postexposure exercise, respectively). No
difference between preexercise low [PM1] and preexercise high
[PM1] basal brachial artery diameter was noted (4.66 ± 0.626
mm vs. 4.66 ± 0.609 mm, respectively).
High PM1 inhalation during exercise resulted in a reduction in
FMD (Figure 2). FMD was significantly impaired after 30 min
of high [PM1] exercise (6.8 ± 3.58% vs. 0.3 ± 02.74% for
pre- and postexercise measurements, respectively; p = .0001).
Under low [PM1] conditions, preexercise FMD (6.6 ± 4.04%)
and postexercise FMD (4.9 ± 4.42%) were not different. Post
high [PM1] exercise FMD was significantly less than pre and
postlow [PM1] exercise FMD ( p = .0001, p = .003, respectively); preexercise high [PM1] FMD was not different than preor postexercise [PM1] FMD values.
For low [PM1] conditions, a nonsignificant 3% reduction between pre- and postexercise forearm muscle NIRS reoxygenation slope-to-baseline after release of 4 min cuff ischemia was
noted (13.9 ± 7.80 μMs−1
vs. 13.5 ± 7.44 μMs−1
for preexercise and postexercise, respectively; Figure 3). For high [PM1]
conditions, a significant 55% reduction between pre- and postexercise in NIRS reoxygenation slope-to-baseline after release of
4 min cuff ischemia was identified (14.3 ± 6.80 μMs−1
vs. 6.4 ±136 K. W. RUNDELL ET AL.
FIG. 2. Flow-mediated vasodilation of the brachial artery expressed as percent increase from basal diameter. Note the significantly blunted vasodilation after high [PM1] exercise ( p =
.0001). Pre-EX, preexposure, Post-EX, postexposure. Values
presented as mean ± SE.
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